Hello Avatar! Welcome to the BowtiedBiotech podcast, where science meets business! If you're fascinated by breakthrough biotech, bold innovations, and the business behind the science, you're in the right place. Each week, we dive into the world of biotech with fresh insights, sharp analysis, and the stories that are shaping the future of health. Whether you’re an industry insider, an investor, or just biotech-curious, we’ve got something for you.
We are now publishing 7x per week according to the following cadence:
Mondays: Stocks
Tuesdays: Biotech
Wednesdays: Podcast
Thursdays: Markets
Fridays: News
Saturdays: Podcast
Sundays: Strategy
We are also publishing unique content on X - be sure to follow up if you are not already @BowTiedBiotech. And to check-out the archive of our work on X you can find it on our website at: BowtiedBiotech.subtack.com/x-articles.
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In this episode, we dive into the next chapter of mRNA therapeutics. While most people still associate mRNA with COVID-19 vaccines, the science has rapidly evolved. We’re now seeing breakthroughs that push far beyond infectious disease—into cancer, rare disorders, and even autoimmune conditions. From re-engineering lipid nanoparticles for precise tissue delivery to designing mRNA that only turns on in specific cells, the field is undergoing a quiet revolution. Add in machine learning, modular regulatory frameworks, and real clinical momentum, and the road ahead looks wide open. Today, we unpack where the science is going, what it means for investors, and how close we really are to seeing mRNA deliver on its broader promise.
📣🎙️ TODAY’S PODCAST:
[ 0:00 ] Intro & Setup
[ 0:33 ] mRNA Beyond Vaccines
[ 1:27 ] Delivery Challenges
[ 2:35 ] LNP Innovation
[ 3:43 ] Tissue Targeting
[ 5:12 ] Codon Optimization
[ 6:58 ] miRNA Logic Gates
[ 8:40 ] Big Data Design
[10:46 ] Modular Regulation
[13:25 ] Disease Applications
[15:14 ] Future Outlook
[17:01 ] Outro
CONCLUSION
We hope you are enjoying our first leap into the podcast world! Instead of waiting until everything is perfect, we’re diving in and will continue improving as we go. Feel free to send us your suggestions, feedback, or constructive criticism—we’d love to hear from you!
As a reminder, if looking to go deeper into the topics we cover check out our website BowTiedBiotech.com, or DM us on twitter, or email us: bowtiedbiotech@gmail.com
ABOUT BOWTIEDBIOTECH
As a reminder, the purpose of the BowTiedBiotech substack is two-fold. Primarily, we aim to provide our scientist audience the tools to build a biotech company and ultimately translate their ideas into medicines for patients. Secondarily, biotech investors may find this substack useful as we will be providing weekly market updates of the public AND private markets as well as heavily leveraging current financing events as teaching examples.
DISCLAIMER
None of this is to be deemed legal or financial advice of any kind. All updates are sourced from publicly available disclosures. Insights are *opinions* written by an anonymous cartoon/scientist/investor.
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